COVID-19: A complex disease with a unique metabolic signature.
| Autor: | Veronica Ghini, Walter Vieri, Tommaso Celli, Valentina Pecchioli, Nunzia Boccia, Tania Alonso-Vásquez, Lorenzo Pelagatti, Marco Fondi, Claudio Luchinat, Laura Bertini, Vieri Vannucchi, Giancarlo Landini, Paola Turano |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | PLoS Pathogens, Vol 19, Iss 11, p e1011787 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1553-7366 1553-7374 |
| DOI: | 10.1371/journal.ppat.1011787 |
| Popis: | Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature, revealed by the NMR analysis of a cohort of >500 patients sampled during various waves of COVID-19 infection, corresponding to the spread of different variants, and having different vaccination status. This composite signature highlights common traits of the SARS-CoV-2 infection. The most dysregulated molecules display concentration trends that scale with disease severity and might serve as prognostic markers for fatal events. Metabolomics evidence is then used as input data for a sex-specific multi-organ metabolic model. This reconstruction provides a comprehensive view of the impact of COVID-19 on the entire human metabolism. The human (male and female) metabolic network is strongly impacted by the disease to an extent dictated by its severity. A marked metabolic reprogramming at the level of many organs indicates an increase in the generic energetic demand of the organism following infection. Sex-specific modulation of immune response is also suggested. |
| Databáze: | Directory of Open Access Journals |
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