| Autor: |
Ji Hye Kim, Mi Jeong Jo, Hye Jin Go, Nam Gyu Park, Gun Do Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 13, Iss 4 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| DOI: |
10.3329/bjp.v13i4.37351 |
| Popis: |
Mastoparan B (MP-B), a cationic tetradecapeptide isolated from the venom of the Vespa basalis, exhibits cardiovascular effects, local edema and antibacterial activity. In this study, the anti-adipogenic effect of an MP-B analogue and its mechanism of action in 3T3-L1 preadipocytes were studied. The MP-B analogue (MP-B12) inhibited preadipocyte differentiation and decreased the expression of adipogenic transcription factors, including CCAAT/enhancer binding protein-alpha (C/EBPα), nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) and sterol regulatory element-binding protein-1 (SREBP-1). Moreover, MP-B12 regulated the phosphorylation of Akt and glycogen synthase kinase-3 beta (GSK-3β), both of which play a role in preadipocyte differentiation, in which insulin and certain growth factors stimulated adipogenesis. This study demonstrates that MP-B12 inhibits preadipocyte differentiation and the accumulation of lipid droplets in 3T3-L1 preadipocytes and could potentially be used to treat obesity. Video Clip of Methodology: 4 min 11 sec Full Screen Alternate |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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