Dawn of Targeted Therapy Using Claudin18.2 for Gastric Cancer

Autor: LI Hao, YE Xianhui, ZHOU Junjie, LI Xiaofen
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Zhongliu Fangzhi Yanjiu, Vol 50, Iss 10, Pp 1022-1028 (2023)
Druh dokumentu: article
ISSN: 1000-8578
DOI: 10.3971/j.issn.1000-8578.2023.23.0164
Popis: In recent years, significant advancements in molecular biology have paved the way for novel targeted therapeutic strategies for gastric cancer treatment. Claudin18, which is an important structural protein involved in tight junctions between cells, and its subtype Claudin18.2 (CLDN18.2), which is specifically expressed in differentiated gastric epithelial cells, have emerged as novel therapeutic targets for patients with gastric cancer. This article aims to systematically review the latest developments in CLDN18.2 research in the fields of basic and clinical gastric cancer studies to provide a reference for clinical practice.
Databáze: Directory of Open Access Journals