Does pathological type of primary nephrotic syndrome affect serum concentrations of proprotein convertase subtilisin/kexin type 9?

Autor: Howayda El Shinnawy, Abubakr Mohamed Fahmy, Mohamed Sary Gharib
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Egyptian Journal of Internal Medicine, Vol 34, Iss 1, Pp 1-6 (2022)
Druh dokumentu: article
ISSN: 1110-7782
2090-9098
DOI: 10.1186/s43162-022-00157-1
Popis: Abstract Background Dyslipidemia is a common finding in primary nephrotic syndrome (PNS). Serum PCSK9 level is also increased in PNS and is the main cause of dyslipidemia in such patients. There is a paucity of data on the relation between dyslipidemia and pathological types of PNS. We hypothesized that severity of dyslipidemia varies across different types of PNS, and this variation is due to differences in serum PCSK9 levels. Methods Fifty patients recently diagnosed with PNS were included in this cross-sectional study. Serum PCSK9, albumin, creatinine, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG), and 24-h urine protein were measured. Comparison of patients’ characteristics between pathological types of PNS and correlations between serum PCSK9 and other parameters were assessed. Results Serum PCSK9 levels were significantly higher in PNS patients compared with healthy individuals (314.58 ± 73.83 vs 253.42 ± 36.66 ng/ml, p
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