| Autor: |
Hui-Fang Zhang, Lei Ma, Feng Su, Xiao-Fang Ma, Tao Li, Wu Jian-Zha-Xi, Guo-Hu Zhao, Zi-Mao Wu, Cai-lan Hou, Hai-jun Yan |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Polymer Testing, Vol 103, Iss , Pp 107375- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0142-9418 |
| DOI: |
10.1016/j.polymertesting.2021.107375 |
| Popis: |
As a natural polymer, there are a lot of functional groups on the keratin molecular chains, such as carboxyl, amino and hydroxyl groups. In the present study, we used keratin (K) as a multifunctional crosslinker and prepared smart nanogels. The nanogels had high loading capacity for drug, while low drug leakage. The surface of the DOX@K/SA-NG is negatively charged and the size was determined to be 432 nm. The nanogels had drug loading capacity (DLC) of 65.2% (w/w) and were capable of triggering drug release upon both pH and reductive (glutathione (GSH)) environment while stable under physiological conditions (pH 7.4 + 10 μM GSH). We evaluated its cancer treatment performance through cell uptake and cytotoxicity experiments, it showed that the prepared DOX@K/SA-NG can effectively inhibit the growth of HepG2 cancer cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect