Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations

Autor: Laura Orellana, Ozge Yoluk, Oliver Carrillo, Modesto Orozco, Erik Lindahl
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12575
Popis: Protein conformational changes are key to a wide range of cellular functions but remain difficult to access experimentally. Here the authors describe eBDIMS, a novel approach to predict intermediates observed in structural transition pathways from experimental ensembles.
Databáze: Directory of Open Access Journals