Nasal steroid use and osteitis development in chronic rhinosinusitis with nasal polyps

Autor: Sadullah Şimşek, Akif İşlek
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Egyptian Journal of Otolaryngology, Vol 38, Iss 1, Pp 1-6 (2022)
Druh dokumentu: article
ISSN: 1012-5574
2090-8539
DOI: 10.1186/s43163-022-00328-5
Popis: Abstract Objectives Osteitis and tissue remodeling are inflammatory processes associated with the severity of chronic rhinosinusitis with nasal polyps (CRSwNP). Nasal steroids are the mainly recommended therapeutics in the treatment of the disease, and besides their beneficial effects, they may worsen osteitis via osteopenia. This study aimed to search for the coalescence of osteitis in CRSwNP and nasal steroid use (NSU). Methods A cross-sectional study was designed. Patients who underwent paranasal sinus computed tomography (PNSCT) imaging were queried, and the sino‐nasal outcome test-22 (SNOT-22) was completed. Regular NSU was defined as a continued treatment for 2 months in the last 6 months. The cumulative period of NSU during the last 6 months was determined and classified as no use or, for 1 to 3 months, or more than 3 months. Lund-MacKay scores (LMS) and Global Osteitis Scores (GOS) were calculated for 10 sinuses via PNSCT. Results Sixty-two patients were included in the study. The mean GOS score was 5.7 ± 1.7 points higher in patients with regular NSU (p = 0.002, 95% CI: 9.2–2.2, t-test). LMS and SNOT-22 scores also were significantly higher for patients with regular NSU (p = 0.036 and
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