Nivolumab‐induced liver injury with a steroid‐refractory increase in biliary enzymes, in a patient with malignant mesothelioma: An autopsy case report

Autor: Kazumori Arai, Masanori Matsuda, Hiromasa Nakayasu, Shiori Meguro, Takafumi Kurokami, Aki Kubota, Tomohiro Iwasaki, Makoto Suzuki, Shinya Kawaguchi, Toshihide Iwashita
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical Case Reports, Vol 9, Iss 12, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 2050-0904
DOI: 10.1002/ccr3.5174
Popis: Abstract This is the first autopsy report of hepatotoxicity from nivolumab immunotherapy for malignant mesothelioma. The increase in levels of biliary enzymes and randomly distributed endothelial damage were steroid‐refractory, but second‐line option was abandoned because of cachexia. Further discussions are needed regarding the customized management of immune‐related toxicities.
Databáze: Directory of Open Access Journals
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