| Autor: |
Chenghai Yang, Le Liu, Jerry Kitbok Majaw, Liping Liang, Ye Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Medicine in Microecology, Vol 8, Iss , Pp 100036- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0978 |
| DOI: |
10.1016/j.medmic.2021.100036 |
| Popis: |
Aims: To investigate the effects of Lactobacillus reuteri supplementation on the eradication rate of H. pylori and the treatment-related adverse effects caused by anti-H. pylori therapies. Methods: The authors conducted independent searches of PubMed, Medline, Embase and Cochrane library from the inception of this study until May 2021 and extracted data from eligible randomised controlled trials published in English that compared Lactobacillus reuteri supplementation to placebo or no treatment during anti-H. pylori therapies. Review Manager 5.3 was used for all statistical analyses. Results: Six randomized controlled trials involving 378 patients were included in the analysis. An intention-to-treat analysis via a fixed-effects model showed that the pooled relative risk (RR) for the eradication rate was higher for the Lactobacillus reuteri supplementation group than for the control group, but the difference was not significant [RR 1.12, 95% confidence interval (CI): 0.98–1.27, P = 0.09). The incidence of total antibiotic-related side effects was lower in the Lactobacillus reuteri supplementation group than in the control group, with a pooled RR value of 0.55 (95% CI: 0.39–0.77, P = 0.0006), which was determined using a fixed-effects model. Certain adverse events, such as diarrhoea (RR = 0.31, 95% CI: 0.19–0.52, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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