Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected

Autor:	Kelvin M. Kimenyi, Mercy Y. Akinyi, Kioko Mwikali, Tegan Gilmore, Shaban Mwangi, Elisha Omer, Bonface Gichuki, Juliana Wambua, James Njunge, George Obiero, Philip Bejon, Jean Langhorne, Abdirahman Abdi, Lynette Isabella Ochola-Oyier
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Malaria Asymptomatic Plasmodium falciparum infection Immunity Host-parasite interactions Infectious and parasitic diseases RC109-216
Zdroj:	BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-15 (2024)
Druh dokumentu:	article
ISSN:	1471-2334
DOI:	10.1186/s12879-024-08973-2
Popis:	Abstract Background Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance of chronic symptomless infections that sustain malaria transmission. Methods Here, we determined the gene expression profiles of the parasite population and the corresponding host peripheral blood mononuclear cells (PBMCs) from 21 children (
Databáze:	Directory of Open Access Journals
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