Promising clinical and immunological efficacy of Bacillus clausii spore probiotics for supportive treatment of persistent diarrhea in children

Autor:	Ha Thuy Dang, Dien Minh Tran, Thuy Thi Bich Phung, Anh Thi Phuong Bui, Yen Hai Vu, Minh Thi Luong, Hang Minh Nguyen, Huong Thi Trinh, Tham Thi Nguyen, Anh Hoa Nguyen, Anh Thi Van Nguyen
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Persistent diarrhea Probiotic Bacillus clausii Spore Cytokine Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-56627-9
Popis:	Abstract Persistent diarrhea is a severe gastroenteric disease with relatively high risk of pediatric mortality in developing countries. We conducted a randomized, double-blind, controlled clinical trial to evaluate the efficacy of liquid-form Bacillus clausii spore probiotics (LiveSpo CLAUSY; 2 billion CFU/5 mL ampoule) at high dosages of 4–6 ampoules a day in supporting treatment of children with persistent diarrhea. Our findings showed that B. clausii spores significantly improved treatment outcomes, resulting in a 2-day shorter recovery period (p
Databáze:	Directory of Open Access Journals
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