Study of blood microcirculation of pancreas in rats with alloxan diabetes by Laser Speckle Contrast Imaging

Autor: Polina A. Timoshina, Alla B. Bucharskaya, Denis A. Alexandrov, Valery V. Tuchin
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Biomedical Photonics & Engineering, Vol 3, Iss 2 (2017)
Druh dokumentu: article
ISSN: 2411-2844
DOI: 10.18287/JBPE17.03.020301
Popis: The blood microcirculation of the pancreas in rats with diabetes was studied using Laser Speckle Contrast Imaging (LSCI). The impact on blood flow of x-ray contrast “OmnipaqueTM-300” (n = 1.438) and aqueous solution of “OmnipaqueTM-300” (n = 1.407) used as optical clearing agents (OCAs) was also investigated. The alloxan induced animal model of diabetes was exploited. The results obtained in the study of blood microcirculation disorders of pancreas in diabetes and under topical application of optical clearing agents show that disease development in animals causes changes in the microcirculatory system response to application of “OmnipaqueTM-300” solutions.
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