Vagus nerve stimulation parameters evoke differential neuronal responses in the locus coeruleus

Autor:	Ariana Farrand, Vincent Jacquemet, Ryan Verner, Misty Owens, Eric Beaumont
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	bursting paradigm in vivo electrophysiology locus coeruleus neural activity neuronal synchrony vagus nerve stimulation Physiology QP1-981
Zdroj:	Physiological Reports, Vol 11, Iss 5, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2051-817X
DOI:	10.14814/phy2.15633
Popis:	Abstract Vagus nerve stimulation (VNS) is used to treat drug‐resistant epilepsy and depression, with additional applications under investigation. The noradrenergic center locus coeruleus (LC) is vital for VNS effects; however, the impact of varying stimulation parameters on LC activation is poorly understood. This study characterized LC activation across VNS parameters. Extracellular activity was recorded in rats' left LC while 11 VNS paradigms, utilizing variable frequencies and bursting characteristics, were pseudorandomly delivered to the left cervical vagus for five cycles. Neurons' change from baseline firing rate and timing response profiles were assessed. The proportion of neurons categorized as responders over 5 VNS cycles doubled in comparison to the first VNS cycle (p
Databáze:	Directory of Open Access Journals
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