Effect of a single dose of esmolol on the bispectral index to endotracheal intubation during desflurane anesthesia
| Autor: | Eun Mi Choi, Kyeong Tae Min, Jeong Rim Lee, Tai Kyung Lee, Seung Ho Choi |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Korean Journal of Anesthesiology, Vol 64, Iss 5, Pp 420-425 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2005-6419 2005-7563 |
| DOI: | 10.4097/kjae.2013.64.5.420 |
| Popis: | BackgroundIn this prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of a single dose of esmolol on the bispectral index (BIS) to endotracheal intubation during desflurane anesthesia.MethodsAfter induction of anesthesia, 60 patients were mask-ventilated with desflurane (end-tidal 1 minimum alveolar concentration) for 5 min and then received either normal saline, esmolol 0.5 or 1 mg/kg, 1 min prior to intubation (control, esmolol-0.5 and esmolol-1 groups, n = 20/group). BIS, mean arterial pressure, and heart rate were measured prior to anesthesia induction and esmolol administration, immediately preceding intubation (time point 0), and every minute for 5 min after intubation (time point 1 to 5). At time point 0, 1 and 5, 5 ml of arterial blood was taken to measure plasma concentrations of norepinephrine and epinephrine.ResultsBIS increased significantly at 1 min after intubation when compared with pre-intubation values in all groups. Both mean arterial pressure and heart rate increased significantly 1 min after intubation when compared with preintubation values for all groups. Plasma epinephrine concentrations did not increase significantly after tracheal intubation in any of the groups. Norepinephrine increased at 1 min after intubation when compared with the preintubation values in the esmolol groups (P < 0.05).ConclusionsA single bolus of esmolol was unable to blunt the increase in BIS to endotracheal intubation during desflurane anesthesia. |
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