Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1

Autor:	Zhaopeng Shi, Guifang Gan, Xiang Xu, Jieying Zhang, Yuan Yuan, Bo Bi, Xianfu Gao, Pengfei Xu, Wenbin Zeng, Jixi Li, Youqiong Ye, Aiwu Zhou, Naixia Zhang, Wen Liu, Shuhai Lin, Jun Mi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	3-Hydroxyanthronic acid (3-HAA) Kynurenine YY1 DUSP6 Hepatocellular carcinoma (HCC) Tryptophan metabolism Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)
Druh dokumentu:	article
ISSN:	1756-8722
DOI:	10.1186/s13045-021-01165-4
Popis:	Abstract The 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in hepatocellular carcinoma by binding YY1. This 3-HAA binding of YY1 leads to phosphorylation of YY1 at the Thr 398 by PKCζ, concomitantly enhances YY1 chromatin binding activity to increase expression of target genes. These findings demonstrate that 3-HAA is a ligand of YY1, suggesting it is a promising therapeutic candidate for HCC.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3d499d84ce3e48009a0009c6b1acc40d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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