Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer
| Autor: | Young Min Jo, Tae In Park, Hwa Young Lee, Ji Yun Jeong, Won Kee Lee |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of Pathology and Translational Medicine, Vol 50, Iss 2, Pp 122-128 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2383-7837 2383-7845 |
| DOI: | 10.4132/jptm.2015.10.31 |
| Popis: | Background: Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC). Methods: Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed. Results: AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p |
| Databáze: | Directory of Open Access Journals |
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