Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes
| Autor: | Souza Da Silva Ricella M., Queiroga Eduardo M., de Toledo Osório Cynthia A.B., Cunha Karin S., Dias Eliane P. |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Archive of Oncology, Vol 28, Iss 1, Pp 1-6 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0354-7310 1450-9520 |
| DOI: | 10.2298/AOO210403003S |
| Popis: | Background: Our aim was to explore relevance of the proportion between neoplastic cell component and tumor-associated stroma in order to assess its association with confirmed aggressive phenotypes of right/left colon and rectum cancers in a large series of patients. Methods: The quantification of stroma component was performed in patients diagnosed with colorectal adenocarcinoma who underwent surgical resection. The analyzed variables were age, gender, anatomical/pathological features, and tumor-stroma proportion. Tumor-stroma proportion was estimated based on slides used in routine pathology for determination of T status and was described as low, with a stromal percentage ≤50% or high, with a stromal percentage >50%. The tumor-stroma proportion was estimated by two observers, and the inter-observer agreement was assessed. Results: The sample included 390 colorectal adenocarcinoma patients. Stroma-rich tumors were observed in 53.3% of cases. Well-differentiated tumors had the lowest stromal proportions (p = 0.028). Stroma-poor tumors showed less depth of invasion (p |
| Databáze: | Directory of Open Access Journals |
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