Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report
| Autor: | Luís Otávio Sales Ferreira Caboclo, Nancy Huang, Guilherme Alves Lepski, José Antônio Livramento, Carlos Alberto Buchpiguel, Cláudia Sellitto Porto, Ricardo Nitrini |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 60, Iss 2B, Pp 458-461 (2002) |
| Druh dokumentu: | article |
| ISSN: | 1678-4227 0004-282X |
| DOI: | 10.1590/S0004-282X2002000300022 |
| Popis: | We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil. |
| Databáze: | Directory of Open Access Journals |
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