| Autor: |
Michiko Matsuse, Norisato Mitsutake |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Endocrine Journal, Vol 70, Iss 11, Pp 1035-1049 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1348-4540 |
| DOI: |
10.1507/endocrj.EJ23-0136 |
| Popis: |
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and have emerged to play critical roles in tumor progression. The mutations upregulate TERT transcription, and TERT not only elongates telomeres and confers unlimited proliferative capacity on tumor cells, but is also involved in tumor progression and aggressiveness. In differentiated thyroid carcinoma, TERT-p mutations are associated with a number of high-risk clinicopathological aggressiveness and worse prognosis, making it the best molecular marker to predict tumor aggressiveness so far. This review summarizes recent relevant findings regarding TERT-p mutations and their functional/mechanistic aspects. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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