Genetic profile of sports climbing athletes from three different ethnicities
| Autor: | Mika Saito, Michał Ginszt, Ekaterina Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michałowska-Sawczyn, Hiroki Homma, Paweł Cięszczyk, Takanobu Okamoto, Andrey Larin, Edward Generozov, Piotr Majcher, Koichi Nakazato, Ildus Ahmetov, Naoki Kikuchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Biology of Sport, Vol 39, Iss 4, Pp 913-919 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0860-021X 2083-1862 |
| DOI: | 10.5114/biolsport.2022.109958 |
| Popis: | This study aimed to investigate the ACTN3 R577X, ACE I/D, CKM rs8111989, and TRHR rs7832552 genotypes in climbers and controls in three ethnicities. The study consisted of 258 climbers (Japanese, n = 100; Polish, n = 128; Russian, n = 30) and 1151 controls (Japanese: n = 332, Polish: n = 635, Russian: n = 184). Genotyping results were analyzed using the TaqMan approach in Japanese and Polish subjects and HumanOmni1-Quad Bead Chips in Russian subjects. There were no significant differences in ACTN3 R577X and ACE I/D polymorphism distribution between climbers and controls in any ethnic cohort or model. The frequencies of the C allele in the CKM polymorphism and the T allele in the TRHR polymorphism were higher in climbers than in controls only in the Russian cohort (p = 0.045 and p = 0.039, respectively). The results of the meta analysis on three cohorts showed that the frequency of XX+RX genotypes in the ACTN3 R577X polymorphism was significantly higher in climbers than that in the controls (p = 0.01). The X allele of the ACTN3 R577X polymorphism was associated with sport climbing status, as assessed using a meta-analysis of climbers across three different ethnicities. |
| Databáze: | Directory of Open Access Journals |
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