Apium graveolens L. alleviates acute lung injury in human A-549 cells by reducing NF-κB and NLRP3 inflammasome signaling
| Autor: | Lan-Chi Hsieh, Shu-Ling Hsieh, Tsu-Ni Ping, Yi-Chun Huang, Ssu-Jung Lin, Hsing-Yu Chi, Chih-Chung Wu |
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| Jazyk: | angličtina |
| Rok vydání: | 2025 |
| Předmět: | |
| Zdroj: | Pharmaceutical Biology, Vol 63, Iss 1, Pp 1-13 (2025) |
| Druh dokumentu: | article |
| ISSN: | 13880209 1744-5116 1388-0209 |
| DOI: | 10.1080/13880209.2024.2433994 |
| Popis: | Background Apium graveolens L. (celery) is a dietary vegetable with anti-inflammatory properties. It has the potential to treat acute lung injury (ALI) caused by COVID-19 or other diseases.Objective To investigate the effects of Apium graveolens water extract (AGWE) on ALI in human lung A-549 cells induced by lipopolysaccharide (LPS).Materials and methods A-549 cells were treated with AGWE for 24 h and then stimulated with 10 μg/mL LPS for another 24 h. The effects of AGWE on cell viability, the inflammatory response, oxidative stress, and apoptosis and their regulatory factors, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling activation were analyzed.Results Treatment with 5–50 μg/mL AGWE reversed the decrease in cell viability caused by LPS (p |
| Databáze: | Directory of Open Access Journals |
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