Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation

Autor:	Winnie WY Ip, Waseem Qasim
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Advances in Hematology, Vol 2013 (2013)
Druh dokumentu:	article
ISSN:	1687-9104 1687-9112
DOI:	10.1155/2013/176418
Popis:	Adenovirus (ADV) can cause significant morbidity and mortality in children following haematopoietic stem cell transplantation (HSCT), with an incidence of up to 27% and notable associated morbidity and mortality. T-cell depleted grafts and severe lymphopenia are major risk factors for the development of adenovirus disease after HSCT. Current antiviral treatments are at best virostatic and may have significant side effects. Adoptive transfer of donor-derived virus-specific T cells has been shown to be an effective strategy for the prevention and treatment of ADV infection after HSCT. Here we review progress in the field and present a pathway for the management of adenovirus in the posttransplant setting.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d3d0a062e35d4a4d88fc6462c2ec05da Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF