Angiopoietin-like 2 is essential to aortic valve development in mice

Autor: Pauline Labbé, Victoria Munoz Goyette, Nathalie Thorin-Trescases, Louis Villeneuve, Ines Desanlis, Constance Delwarde, Yan-Fen Shi, Cécile Martel, Carol Yu, Azadeh Alikashani, Maya Mamarbachi, Frédéric Lesage, Samuel Mathieu, Jean-Claude Tardif, Patrick Mathieu, Marie Kmita, Éric Thorin
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-04243-6
Popis: Mice knockdown for Angiopoietin-like 2 (Angptl2) exhibit spontaneous aortic valve stenosis associated with a decrease in Notch signalling and an imbalance in cell apoptosis, senescence and proliferation during embryonic valve remodelling stage.
Databáze: Directory of Open Access Journals
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