Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives

Autor: Li-Ming Hu, Ru-gang Zhong, Zi-Guo Jiao, Cheng-Chu Zeng, Yi-Sheng Xu
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Molecules, Vol 14, Iss 2, Pp 868-883 (2009)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules14020868
Popis: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
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