The Effects of Aerobic Exercise on NF-κB and TNF-α in Lung Tissue of Male Rat
| Autor: | Mohamad Fashi, Hamid Agha-Alinejad, Hasan Asilian Mahabadi, Batul Rezaei, Behzad Behzad Pakrad, Sajad Rezaei |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Novelty in Biomedicine, Vol 3, Iss 3, Pp 131-134 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2345-3346 2345-3907 |
| Popis: | Background:Regular aerobic exercise improves theBackground: Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the lung response have not been investigated. The present study evaluated the effect of aerobic exercise on the lung inflammatory.Materials and Methods: 12 adult male Wistar rats were divided to 2 groups: A: control (n=6), B: aerobic exercise (five times per week for 4 week; n=6). The gene expression of NF-κB and TNF-α were analyzed in lung tissue by Real time–PCR. In order to determine the significant differences between groups independent t-test were used.Results: Aerobic exercise inhibited the gene expression of NF-κB and TNF-α. But there was no significant difference between A and B groups for TNF-α and NF-κB.Conclusion: We conclude that four week aerobic exercise decrease inflammatory status in lung tissue. Our results indicate a need for human studies that evaluate the lung responses to aerobic exercise. |
| Databáze: | Directory of Open Access Journals |
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