Impact of Human Cytomegalovirus Infection and its Immune Response on Survival of Patients with Ovarian Cancer

Autor: Angelique Flöter Rådestad, Atosa Estekizadeh, Huanhuan L Cui, Ourania N. Kostopoulou, Belghis Davoudi, Angelica Lindén Hirschberg, Joseph Carlson, Afsar Rahbar, Cecilia Söderberg-Naucler
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Translational Oncology, Vol 11, Iss 6, Pp 1292-1300 (2018)
Druh dokumentu: article
ISSN: 1936-5233
DOI: 10.1016/j.tranon.2018.08.003
Popis: Human cytomegalovirus (HCMV) has been detected in various types of tumors. We studied the prevalence of HCMV in ovarian cancer and its relation to clinical outcome. Paraffin-embedded tissues obtained prospectively from 45 patients with ovarian cancer and 30 patients with benign ovarian cystadenoma were analyzed for expression of HCMV immediate-early protein (IE) and HCMV tegument protein (pp65) by immunohistochemistry. Plasma was analyzed for HCMV serology. HCMV-IgG levels were higher in patients with ovarian cancer or benign cystadenoma than in age-matched controls (P = .002, P
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