| Autor: |
Yukie Yoshida, Kazumasa Hashimoto, Hidehisa Saeki, Fumiaki Itagaki, Akio Hirama, Atsuko Suzuki, Kayo Iiyama, Yumi Fukunaga, Hiroyuki Enomoto, Eiji Kushima, Momoyo Kishida, Seiki Fujimoto, Shuichi Tsuruoka |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Kidney Medicine, Vol 1, Iss 4, Pp 191-199 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0595 |
| DOI: |
10.1016/j.xkme.2019.04.008 |
| Popis: |
Background: In dialysis patients, skin disorders (dryness and itching) are frequently observed and treated with a moisturizer, in the absence of clear evidence of efficacy. Study Design: An open-label, randomized, before/after, parallel-group, comparative/exploratory study. Setting & Participants: 12 Japanese patients with chronic kidney failure undergoing maintenance hemodialysis who presented with dry skin and itching. Intervention: Patients received a topical heparinoid moisturizer as the study drug for 2 weeks from the first day of the study treatment, followed by either a 2-week washout (group A: 6 participants) or further 2-week treatment (group B: 6 participants). Outcomes: The primary end point was change in water content in the stratum corneum in the hypochondrium. Secondary end points included change in visual analogue scale itching score and subjective evaluations of symptoms. To evaluate safety, adverse events were also investigated. Measurements: Water content of the stratum corneum, dryness/itching improvement rating, itching visual analogue scale/duration of itching, photographic evaluation of skin symptoms, principal investigator’s overall assessment of study drug, and adverse events. Results: Mean water content of the stratum corneum in the combined groups significantly increased at week 2 (51.2 arbitrary units [AU] vs treatment start day, 31.6 AU; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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