| Autor: |
Andrew Blauvelt, Yanqing Chen, Patrick J. Branigan, Xuejun Liu, Samuel DePrimo, Brice E. Keyes, Monica Leung, Steven Fakharzadeh, Ya-Wen Yang, Ernesto J. Muñoz-Elías, James G. Krueger, Richard G. Langley |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JID Innovations, Vol 4, Iss 5, Pp 100297- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2667-0267 |
| DOI: |
10.1016/j.xjidi.2024.100297 |
| Popis: |
IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis. IL-23 activation initiates a cascade of cytokines subsequently inducing the expression of many psoriasis-related proteins. This study aimed to better understand the underlying mechanisms driving the differences between IL-23 and IL-17A blockade in patients with psoriasis and their implications for durability of clinical responses. Serum and/or skin biopsies were isolated from patients treated with guselkumab or secukinumab for evaluation of potential biomarkers of pharmacodynamic response to treatment. Guselkumab treatment led to significantly greater reductions of IL-17F and IL-22 serum levels than treatment with secukinumab at weeks 24 and 48, demonstrating sustained regulation of the IL-23/T helper 17 pathway. Analyses of proteomic and transcriptomic profiles of patient sera and skin biopsies demonstrated differential regulation of proteins involved in chemokine, TNF, and relevant immune signaling pathways to a greater degree with guselkumab than with secukinumab treatment. These data provide insights into the differences between the mechanisms and impact of IL-23 and IL-17A blockade in psoriasis, with implications for efficacy observations and treatment paradigms. Trial Registration: The original study was registered at ClinicalTrials.gov (NCT03090100). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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