| Autor: |
M. Cuellar-Herrera, L. Rocha, N. Saleh-Subaie, F. Velasco, G. Aguado-Carrillo, M. Alonso-Vanegas, R. Guevara-Guzmán, A.L. Velasco |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Revista Médica del Hospital General de México, Vol 81, Iss 4, Pp 177-183 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
0185-1063 |
| DOI: |
10.1016/j.hgmx.2017.07.002 |
| Popis: |
Background: The 5-hydroxytryptamine-1A receptors are known to be involved in the inhibition of seizures in epilepsy. Objective: The main aim of the present study is to determine the functional coupling to G-protein of the 5-HT1A receptor through 8-OH-DPAT-stimulated [35S]GTPγS binding assay in lateral temporal neocortex tissue of patients with mesial temporal lobe epilepsy (mTLE) and correlate it with clinical data. Material and methods: The activation of the G protein complex was determined by [35S]GTPγS binding assay. The temporal neocortex tissue was obtained from 5 patients with mTLE during epilepsy surgery and from 5 subjects (autopsies) who died due to an accident and without history of neurological disease. Results: We found that values of maximal stimulation (Emax) of [35S]GTPγS binding significant decreased in the mTLE group (30.8%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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