| Autor: |
Lujie Wang, Shuling Huang, Zhiyi Feng, Jianyun Xiao, Gaoquan Luo, Yuan Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Nutrition, Vol 11 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2296-861X |
| DOI: |
10.3389/fnut.2024.1384489 |
| Popis: |
BackgroundGrowing evidence suggests a link between vitamin K (VK) intake and depression, although the underlying mechanisms remain unclear. We aimed to investigate whether oxidative balance scores (OBS) mediate the association between VK intake and depression in participants from the National Health and Nutrition Examination Survey (NHANES) 2007–2018.MethodsWe analyzed data from 30,408 individuals. Dietary VK intake served as the independent variable, depression symptoms as the outcome variable, and OBS as the mediator. Multivariable logistic regression and restricted cubic splines assessed the associations. Mediation analysis was conducted to evaluate the potential mediating role of OBS.ResultsHigher dietary VK intake was associated with lower depression risk in the multivariate model. Compared to the lowest log2 VK quartile, those in the higher quartiles had significantly lower depression odds (Q3: OR 0.66, 95% CI 0.55–0.78; Q4: OR 0.64, 95% CI 0.52–0.78). Additionally, a 1-unit increase in log2 VK intake was associated with a 15% decrease in depression odds (OR 0.85, 95% CI 0.81–0.90). Restricted cubic splines revealed a non-linear relationship between log2 VK and depression (p for non-linearity |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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