| Autor: |
Delong Hou, Rui Wang, Zhonghui Wang, Gaofu Yang, Zhou Xu, Qi Zeng, Yi Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Leather Science and Engineering, Vol 3, Iss 1, Pp 1-7 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2524-7859 |
| DOI: |
10.1186/s42825-021-00051-6 |
| Popis: |
Abstract Achieving activatable antibiotics represents one promising solution to tackle the occurrence of side effects, one major issue now plaguing antibiotic usage in collagen-based biomaterials. Despite considerable effort, however, rationale design of activatable antibiotics that display high activation efficiency and uncompromised bactericidal potency in the activated state remains difficult. Here, we demonstrate a design principle that helps to address this challenge. This strategy differs from previous attempts by underscoring photolytic removal of a functionality directly conjugated to the pharmacophore of an antibiotic, enabling not only an activation efficiency significantly improved beyond previous light-activatable antibiotics, but also bactericidal activity in the activated state as potent as the parent drug. Graphical abstract |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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