Regional disparities and risk factors of mortality among patients at high risk of sudden cardiac death in emerging countries: a nonrandomized controlled trial

Autor: Shuang Zhao, Chi-Keong Ching, Dejia Huang, Yen-Bin Liu, Diego A. Rodriguez-Guerrero, Azlan Hussin, Young-Hoon Kim, Brian Van Dorn, Xiaohong Zhou, Balbir Singh, Shu Zhang, the Improve SCA Investigators
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 1741-7015
DOI: 10.1186/s12916-024-03310-5
Popis: Abstract Background Comprehensive data on patients at high risk of sudden cardiac death (SCD) in emerging countries are lacking. The aim was to deepen our understanding of the SCD phenotype and identify risk factors for death among patients at high risk of SCD in emerging countries. Methods Patients who met the class I indication for implantable cardioverter-defibrillator (ICD) implantation according to guideline recommendations in 17 countries and regions underrepresented in previous trials were enrolled. Countries were stratified by the WHO regional classification. Patients were or were not implanted with an ICD at their discretion. The outcomes were all-cause mortality and SCD. Results We enrolled 4222 patients, and 3889 patients were included in the analysis. The mean follow-up period was 21.6 ± 10.2 months. There were 433 (11.1%) instances of all-cause mortality and 117 (3.0%) cases of SCD. All-cause mortality was highest in primary prevention (PP) patients from Southeast Asia and secondary prevention (SP) patients from the Middle East and Africa. The SCD rates among PP and SP patients were both highest in South Asia. Multivariate Cox regression modelling demonstrated that in addition to the independent predictors identified in previous studies, both geographic region and ICD use were associated with all-cause mortality in patients with high SCD risk. Primary prophylactic ICD implantation was associated with a 36% (HR = 0.64, 95% CI 0.531–0.802, p
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