A quantitative expression of KI-67 to assess the malignant transformation potential in oral leukoplakia and erosive lichen planus

Autor: Haranath Danda, Poosarla C Pusarla, Gontu S Reddy, Kattappagari K Kumar, Lalith P Chandra, Baddam V R Reddy
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Dr. NTR University of Health Sciences, Vol 9, Iss 1, Pp 42-45 (2020)
Druh dokumentu: article
ISSN: 2277-8632
DOI: 10.4103/JDRNTRUHS.JDRNTRUHS_77_19
Popis: Introduction: The basic, living, structural and functional unit of the body is known as a 'Cell'.[1] In both embryonic and post-embryonic existence, cell proliferation plays an important role in the biological process of living organisms.[2] The loss of control in the biological process leads to cancer. Leukoplakia and erosive lichen planus (ELP) are potentially malignant disorders. Ki67 is a protein indicative of cell cycle progression and cell proliferation. Aim: To evaluate the quantitative expression of Ki-67 in oral leukoplakia (OL) and ELP. Materials and Methods: Samples were divided into three groups, namely, paraffin-embedded (PE) tissue blocks (10 each) of normal oral mucosa tissue obtained from individuals undergoing third molar surgical removals (Group I); OL (Group II) and ELP (Group III), all of which were confirmed histologically. All the sections were subjected to immunohistochemistry (IHC) using Ki-67, and the number of immunopositive cells was evaluated. Results: Ki-67 positivity in three groups was observed as 31% in controls, 40% in leukoplakia and 36% in ELP. Conclusion: Our study revealed more Ki-67 positivity in leukoplakia than ELP, which indicates more malignant transformation potential for Leukoplakia.
Databáze: Directory of Open Access Journals
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