| Autor: |
Tao Pan, Yueying Gao, Gang Xu, Ping Zhou, Si Li, Jing Guo, Haozhe Zou, Qi Xu, Xiaoyan Huang, Juan Xu, Yongsheng Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2056-7944 |
| DOI: |
10.1038/s41525-022-00304-1 |
| Popis: |
Abstract Transient-receptor potential (TRP) channels comprise a diverse family of ion channels, which play important roles in regulation of intracellular calcium. Emerging evidence has revealed the critical roles of TRP channels in tumor development and progression. However, we still lack knowledge about the genetic and pharmacogenomics landscape of TRP genes across cancer types. Here, we comprehensively characterized the genetic and transcriptome alterations of TRP genes across >10,000 patients of 33 cancer types. We revealed prevalent somatic mutations and copy number variation in TRP genes. In particular, mutations located in transmembrane regions of TRP genes were likely to be deleterious mutations (p-values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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