The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger

Autor: Maria-Cristina Keightley, Duncan P. Carradice, Judith E. Layton, Luke Pase, Julien Y. Bertrand, Johannes G. Wittig, Aleksandar Dakic, Andrew P. Badrock, Nicholas J. Cole, David Traver, Stephen L. Nutt, Julia McCoey, Ashley M. Buckle, Joan K. Heath, Graham J. Lieschke
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14911
Popis: Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by master myeloid regulators and repressesTP53.
Databáze: Directory of Open Access Journals