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INTRODUCTION: The study was conducted to determine the relationship between nursing students' selfefficacy levels and their vocational motivation. METHODS: This descriptive and correlational study was conducted online at a public university in the 2019-2020 academic year, with 406 undergraduate nursing students. Data were collected using the Introductory Information Form, the General Self-Efficacy Scale, and the Scale of Motivation Sources and Problems. Descriptive statistics, independent groups t test, One way ANOVA, correlation, and linear regression tests were used in the analysis of the data. RESULTS: It was determined that 255 (62.8%) female students participated in the study including 123 (30.3%) 2nd grade students and the mean age of the study population was 20.38+-1.83 years. Students' self-efficacy, and professional motivation mean scores were determined as 60.49+-10.15, and 84.93+-11.94, respectively. A highly significant positive correlation was found between the total score averages of the self-efficacy, and motivation scales and the intrinsic motivation subdimension. While gender did not affect self-efficacy and professional motivation, the total scores of self-efficacy and motivation and negative motivation subdimension scores of senior students were found to be high (p |