| Autor: |
Bahira Shahim, Björn Redfors, Brian R. Lindman, Shmuel Chen, Torsten Dahlen, Tamim Nazif, Samir Kapadia, Zachary M. Gertz, Aaron C. Crowley, Ditian Li, Vinod H. Thourani, Susheel K. Kodali, Alan Zajarias, Vasilis C. Babaliaros, Robert A. Guyton, Sammy Elmariah, Howard C. Herrmann, David J. Cohen, Michael J. Mack, Craig R. Smith, Martin B. Leon, Isaac George |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 11 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.121.024091 |
| Popis: |
Background The neutrophil‐to‐lymphocyte ratio (NLR) as a marker of systemic inflammation has been associated with worse prognosis in several chronic disease states, including heart failure. However, few data exist on the prognostic impact of elevated baseline NLR or change in NLR levels during follow‐up in patients undergoing transcatheter or surgical aortic valve replacement (TAVR or SAVR) for aortic stenosis. Methods and Results NLR was available in 5881 patients with severe aortic stenosis receiving TAVR or SAVR in PARTNER (Placement of Aortic Transcatheter Valves) I, II, and S3 trials/registries (median [Q1, Q3] NLR, 3.30 [2.40, 4.90]); mean NLR, 4.10; range, 0.5–24.9) and was evaluated as continuous variable and categorical tertiles (low: NLR ≤2.70, n=1963; intermediate: NLR 2.70–4.20, n=1958; high: NLR ≥4.20, n=1960). No patients had known baseline infection. High baseline NLR was associated with increased risk of death or rehospitalization at 3 years (58.4% versus 41.0%; adjusted hazard ratio [aHR], 1.39; 95% CI, 1.18–1.63; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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