Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles

Autor: Tudor Braniste, Ion Tiginyanu, Tibor Horvath, Simion Raevschi, Birgit Andrée, Serghei Cebotari, Erin C. Boyle, Axel Haverich, Andres Hilfiker
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nanoscale Research Letters, Vol 12, Iss 1, Pp 1-6 (2017)
Druh dokumentu: article
ISSN: 1931-7573
1556-276X
DOI: 10.1186/s11671-017-2262-y
Popis: Abstract In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells. The nanoparticles were synthesized using direct growth of gallium nitride on zinc oxide nanoparticles alloyed with iron oxide followed by core decomposition in hydrogen flow at high temperature. Using transmission electron microscopy, we demonstrate that porcine aortic endothelial cells take up GaN-based nanoparticles suspended in the growth medium. The nanoparticles are deposited in vesicles and the endothelial cells show no sign of cellular damage. Intracellular inert nanoparticles are used as guiding elements for controlled transportation or designed spatial distribution of cells in external magnetic fields.
Databáze: Directory of Open Access Journals
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