Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?

Autor:	J. D. Goldring, M. Hommel
Jazyk:	angličtina
Rok vydání:	1992
Předmět:	malaria cytoadherence thrombospondin ICAM-1 CD36 monocytes sequestration cerebral malaria Plasmodium falciparum Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 87, Pp 313-322 (1992)
Druh dokumentu:	article
ISSN:	0074-0276 1678-8060
DOI:	10.1590/S0074-02761992000700053
Popis:	The sequestration of Plasmodium falciparum-infected erythrocytes to the endothelial cells of brain capillaries is believed to represent one of the determining factors in the pathogenesis of cerebral malaria. In vitro studies of cytoadherence provide an experimental approach to understand the mechanism of sequestration and the respective roles played by parasite and host components in this interaction. This paper critically reviews current studies on cytoadherence, with particular emphasis on the nature of the information provided by such studies and their limitations. The paper also describes how cytoadherence studies using the patient's own monocytes can provide original information on the level of receptor up-regulation in the course of malarial infection.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3c4fecebfd7047fdbae3eef9dc6d17dd Zobrazit plný text záznamu View record in DOAJ