Intra- and Intercellular Quality Control Mechanisms of Mitochondria

Autor: Yoshimitsu Kiriyama, Hiromi Nochi
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Cells, Vol 7, Iss 1, p 1 (2017)
Druh dokumentu: article
ISSN: 2073-4409
DOI: 10.3390/cells7010001
Popis: Mitochondria function to generate ATP and also play important roles in cellular homeostasis, signaling, apoptosis, autophagy, and metabolism. The loss of mitochondrial function results in cell death and various types of diseases. Therefore, quality control of mitochondria via intra- and intercellular pathways is crucial. Intracellular quality control consists of biogenesis, fusion and fission, and degradation of mitochondria in the cell, whereas intercellular quality control involves tunneling nanotubes and extracellular vesicles. In this review, we outline the current knowledge on the intra- and intercellular quality control mechanisms of mitochondria.
Databáze: Directory of Open Access Journals
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