Assessment of Liver Stiffness in Pediatric Fontan Patients Using Transient Elastography

Autor: Becky Chen, Richard A. Schreiber, Derek G. Human, James E. Potts, Orlee R. Guttman
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Canadian Journal of Gastroenterology and Hepatology, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 2291-2789
2291-2797
DOI: 10.1155/2016/7125193
Popis: Background. Hepatic fibrosis is a potential complication following Fontan surgery and heralds long-term risk for cirrhosis. Transient elastography (TE) is a rapid, noninvasive method to assess liver fibrosis by measuring liver stiffness. Objectives. To compare liver stiffness and liver biochemistries in pediatric Fontan patients with age- and sex-matched controls and to determine patients’ acceptance of TE. Methods. Patients were recruited from British Columbia Children’s Hospital. Twenty-two Fontan patients (15 males) were identified. Demographic information and cardiac data were collected. TE was measured using size-appropriate probes. Results. The median age of the Fontan cohort was 13.7 (5.9–16.8) years. Time from Fontan surgery to TE was 9.6 (1.0–12.9) years. The median Fontan circuit pressure was 13 (11–14) mmHg. TE values were higher in Fontan patients versus controls (18.6 versus 4.7 kPa, p
Databáze: Directory of Open Access Journals
Externí odkaz: