Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection

Autor: Judy Chen, Jane C. Deng, Rachel L. Zemans, Karim Bahmed, Beata Kosmider, Min Zhang, Marc Peters-Golden, Daniel R. Goldstein
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34593-y
Popis: Ageing has been associated with impaired function of alveolar macrophages and increased susceptibility, mortality and complications as a result of viral infection. Here, the authors show that prostaglandin E2 is one of the factors responsible for impairing immune defences against influenza during ageing.
Databáze: Directory of Open Access Journals