Studio comparativo H-MRS di indici di N-acetilaspartato ai centri semiovali umani
| Autor: | Bramanti, P, Bruschetta, P, Rotondo, E, Di Pasquale, MR |
|---|---|
| Jazyk: | English<br />Italian |
| Rok vydání: | 2004 |
| Předmět: | |
| Zdroj: | Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, Vol LXXXI-LXXXII, Iss 1, p c1a0401010 (2004) |
| Druh dokumentu: | article |
| ISSN: | 0365-0359 1825-1242 |
| DOI: | 10.1478/c1a0401010 |
| Popis: | Standard INACS, Index of N-actyl-L-aspartate at centrum semiovale obtained by H- MRS, are compared to those of two Groups of volunteers. Group 1 was formed by 30 individuals (65-74 years old) with small cognition deficit probably due to early AD (Alzheimer’s Disease). Mean INACS of Group 1 was lower than the standard (significance = 89,4%, t = 1.64). This suggest that INACS evaluation could help early AD diagnosis. Group 2 was formed by 15 individuals (45-59 years old) with structural damages due to outcomes of Transitory Ischemic Attacks (TIA) or Minor Strokes (MS). In spite of the evident neuronal/axonal degeneration, mean INACS of this Group do not show significative decrease. This could be interpreted on the basis of the presence in the glial cell of N-acetyl derivatives whose resonances overlap the N-acetyl-L-aspartate one masking its lack. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|