| Autor: |
Kaitlin M. Christopherson, Alokananda Ghosh, Abdallah Sherif Radwan Mohamed, Mona Kamal, G. Brandon Gunn, Timothy Dale, Jayashree Kalpathy-Cramer, Jay Messer, Adam S. Garden, Hesham Elhalawani, Steven J. Frank, Jan Lewin, William H. Morrison, Jack Phan, Neil Gross, Renata Ferrarotto, Randal S. Weber, David I. Rosenthal, Stephen Y. Lai, Katherine Hutcheson, Clifton David Fuller, G. Elisabeta (Liz) Marai, Guadalupe Canahuate, David M. Vock, David Fuller |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Clinical and Translational Radiation Oncology, Vol 18, Iss , Pp 16-22 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6308 |
| DOI: |
10.1016/j.ctro.2019.06.005 |
| Popis: |
Objectives: We sought to model chronic radiation-associated dysphagia (RAD) in patients given intensity-modulated radiation therapy (IMRT) for oropharyngeal squamous cell cancer (OPSCC) as a function of age and dose to non-target swallowing muscles. Methods: We reviewed 300 patients with T1-T4 N0-3 M0 OPSCC given definitive IMRT with concurrent chemotherapy. Chronic RAD was defined as aspiration or stricture on videoflouroscopy/endoscopy, gastrostomy tube, or aspiration pneumonia at ≥12 months after IMRT. Doses to autosegmented regions of interest (ROIs; inferior, middle and superior constrictors, anterior and posterior digastrics, mylo/geniohyoid complex, intrinsic tongue, and gengioglossus) were obtained from DICOM-RT plans and dose-volume histograms. The probability of chronic RAD as a function of mean ROI dose, stratified by age ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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