| Autor: |
Hideki Shuto, Atsushi Yamauchi, Munehiko Ikeda, Yoshio Sohda, Ayako Koga, Kohji Tominaga, Takashi Egawa, Yasufumi Kataoka |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 98, Iss 3, Pp 323-326 (2005) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.sc0050046 |
| Popis: |
Hot flushes are the most common complaint of menopausal women. In the present study, a new animal model of hot flushes was established. Tail skin temperature was measured with a thermo tracer after mice were subjected to a forced exercise task using a motor driven treadmill. In ovariectomized mice, forced exercise for 10 min was most effective in increasing tail skin temperature over that of sham-operated mice. This elevation was blocked by estradiol replacement (1 mg/kg per week for 3 weeks), suggesting that our model simulates menopausal hot flushes. Keywords:: ovariectomy, forced exercise, menopausal flushing |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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