Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia

Autor: Heike Stein, Joao Barbosa, Mireia Rosa-Justicia, Laia Prades, Alba Morató, Adrià Galan-Gadea, Helena Ariño, Eugenia Martinez-Hernandez, Josefina Castro-Fornieles, Josep Dalmau, Albert Compte
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18033-3
Popis: Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in NMDAR-dependent short-term synaptic potentiation in these diseases.
Databáze: Directory of Open Access Journals