| Autor: |
Deepak Bushan Raina, Yang Liu, Otto L. P. Jacobson, K Elizabeth Tanner, Magnus Tägil, Lars Lidgren |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Bone & Joint Research, Vol 9, Iss 10, Pp 709-718 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2046-3758 |
| DOI: |
10.1302/2046-3758.910.BJR-2020-0097.R1 |
| Popis: |
Bone is a dynamic tissue with a quarter of the trabecular and a fifth of the cortical bone being replaced continuously each year in a complex process that continues throughout an individual’s lifetime. Bone has an important role in homeostasis of minerals with non-stoichiometric hydroxyapatite bone mineral forming the inorganic phase of bone. Due to its crystal structure and chemistry, hydroxyapatite (HA) and related apatites have a remarkable ability to bind molecules. This review article describes the accretion of trace elements in bone mineral giving a historical perspective. Implanted HA particles of synthetic origin have proved to be an efficient recruiting moiety for systemically circulating drugs which can locally biomodulate the material and lead to a therapeutic effect. Bone mineral and apatite however also act as a waste dump for trace elements and drugs, which significantly affects the environment and human health. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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