Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

Autor:	Elena Hipper, Michaela Blech, Dariush Hinderberger, Patrick Garidel, Wolfgang Kaiser
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	photo-degradation analytical methods post-translational modification protein degradation reactive oxygen species Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 14, Iss 1, p 72 (2021)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics14010072
Popis:	UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques.
Databáze:	Directory of Open Access Journals
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