Method to obtain a plasma rich in platelet- and plasma-growth factors based on water evaporation.

Autor: Jon Mercader Ruiz, Maider Beitia, Diego Delgado, Pello Sánchez, Miren Begoña Sánchez, Jaime Oraa, Fernando Benito-Lopez, Lourdes Basabe-Desmonts, Mikel Sánchez
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PLoS ONE, Vol 19, Iss 2, p e0297001 (2024)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0297001
Popis: Platelet-Rich Plasma, also known as PRP, is an autologous biologic product used in medicine as a treatment for tissue repair. Nowadays, the majority of PRP obtention methods enrich only platelets, not considering extraplatelet biomolecules, which take part in several cell processes. In the present work, a novel PRP preparation method was developed to obtain a PRP rich in both platelet and plasma extraplatelet molecules. The method is based on the evaporation of the water of the plasma using a rotary evaporator. With this new methodology an increase in plasmatic growth factors and, as a consequence, a better dermal fibroblast cell viability was achieved, compared to a standard PRP formulation. This novel PRP product obtained with this new methodology showed promising results in vitro as an improved PRP treatment in future application.
Databáze: Directory of Open Access Journals
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