| Autor: |
Patricia Alegre, Livia Mathias, Maria Angelica Lourenço, Priscila Portugal dos Santos, Andrea Gonçalves, Ana Angélica Fernandes, Paula Schmidt Azevedo Gaiolla, Marcos Ferreira Minicucci, Leonardo Zornoff, Sergio Alberto Rupp Paiva, Bertha Furlan Polegato |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Arquivos Brasileiros de Cardiologia, Vol 114, Iss 1, Pp 78-86 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1678-4170 |
| DOI: |
10.36660/abc.20180140 |
| Popis: |
Abstract Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. Objective: To evaluate the influence of açaí in global ischemia-reperfusion model in rats. Methods: Wistar rats were assigned to 2 groups: Control (C: receiving standard chow; n = 9) and Açaí (A: receiving standard chow supplemented with 5% açaí; n = 10). After six weeks, the animals were subjected to the global ischemia-reperfusion protocol and an isolated heart study to evaluate left ventricular function. Level of significance adopted: 5%. Results: There was no difference between the groups in initial body weight, final body weight and daily feed intake. Group A presented lower lipid hydroperoxide myocardial concentration and higher catalase activity, superoxide dismutase and glutathione peroxidase than group C. We also observed increased myocardial activity of b-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. The systolic function was similar between the groups, and the A group presented poorer diastolic function than the C group. We did not observe any difference between the groups in relation to myocardial infarction area, total and phosphorylated NF-kB, total and acetylated FOXO1, SIRT1 and Nrf-2 protein expression. Conclusion: despite improving energy metabolism and attenuating oxidative stress, açai supplementation did not decrease the infarcted area or improve left ventricular function in the global ischemia-reperfusion model. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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